With new statistical and scientific issues arising in adaptive clinical trial design including the us fdas recent draft guidance a new edition of one of the first books on the topic is needed adaptive design methods in clinical trials second edition reflects recent developments and regulatory positions on the use of adaptive designs in clinical trials it unifies the vast and . Adaptive design methods in clinical trials 2nd revised ed doi 101201 9781584887775 publisher chapman hall authors shein chung chow mark chang boston university second the . Adaptive design methods in clinical trials second edition reflects recent developments and regulatory positions on the use of adaptive designs in clinical trials it unifies the vast and continuously growing literature and research activities on regulatory requirements scientific and practical issues and statistical methodology. 2013 adaptive design methods in clinical trials second edition by s c chow and m chang journal of biopharmaceutical statistics vol 23 no 2 pp 493 495. Adaptive design methods in clinical trials second edition reflects recent developments and regulatory positions on the use of adaptive designs in clinical trials it unifies the vast and continuously growing literature and research activities on regulatory requirements scientific and practical issues and statistical methodology